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Inside the incubator

biotikur: The Startup Transforming How We View Gut Health

Founded by Junayd Mahmood and Isabel Sousa, biotikur creates evidence-based products designed to balance and maintain the gut microbiome. With biotikur’s Brand, Content & Community Lead Emily Phillips now involved in getting the word out, the team is transforming the way we perceive and manage the gut.

Leveraging Science to Improve Gut Health

 

The objective at biotikur is simple: to leverage the new science on gut health and the microbiome to enhance a number of other outcomes linked to the digestive system.

These include common symptoms such as gas and bloating, along with less obvious (but no less relevant) outcomes like mood, weight and metabolism. And while the research is admittedly new – 80% of existing studies on the gut microbiome have been published in the last five years – scientists are increasingly aware of its true impact.

What can consumers anticipate from the startup? According to Emily Phillips, they can expect “bold products developed at the cutting edge of nutritional and scientific research.” Having witnessed the team’s speed and focus during the program, we couldn’t agree more: during this time, biotikur completed multiple product tests and iterations and launched two product lines to the market.

Mahmood adds that biotikur is more than a unique product. He and his team don’t simply want to create a pill people can take to avoid changing anything else in their lifestyle. “That’s kind of an issue,” he adds. “The current system isn’t set up to change any of the root causes of health problems. It just addresses the symptoms.”

This is where biotikur comes in. The young startup aims to embed each product with consciousness and awareness about the body – about what makes people feel good and perform better. There’s also an element of improving one’s nutrition, with the idea of each person taking their health into their own hands.

“There’s a growing sense that all is not well,” says Phillips. “That the planet isn’t well, and that we aren’t well.”

To address this, we must revisit what we consume – that is, what we put into our bodies. And while these aren’t easy changes to make, biotikur is working to improve awareness of gut-healthy lifestyles.

Inspired by Family: Developed for People Everywhere

 

Why the gut microbiome?

It’s all about creating a sense of balance in the gut and beyond, from the mouth throughout the body. The gut contains trillions of bacteria, and when the bad bacteria overtake the good, bad things happen. This imbalance is called dysbiosis.

Dysbiosis can, however, be restored. For one of the startup’s cofounders, restoring it is very much a family affair.

“The idea [for biotikur] originally came because it was becoming more and more of a topic for me personally,” explains Mahmood. “Both of my younger siblings have quite significant digestive issues.”

Mahmood’s younger sister has Coeliac disease – a serious autoimmune disease. His younger brother was prescribed some serious antibiotics around the age of 12 or 13, and he struggled with intensive digestive distress for months at a time. His parents are also type 2 diabetics, which further reinforced his interest in the topic. (Diabetes is linked closely to gut health.)

“Basically, the personal motivation for me to look into this was quite strong,” says the cofounder. “It was kind of a gradual interest and a quite personal story that drew me towards this.”

From there, Mahmood and his team explored the scientific elements of the gut. It’s the blend of science and personal history that fuels the company today.

“If I were doing this purely for economic reasons, then I find that’s not as strong of a day-to-day motivation,” says Mahmood. “But when it’s connected to people you care about, and lots of other people out there, you can deal with the setbacks because you have an extra reserve of motivation.”

With COVID-19 shutting down labs and GMP production facilities, there have been plenty of setbacks this past year in particular. Yet biotikur persists. In the next three years, they hope to cement their reputation as Europe’s premium brand of reference for evidence-based, cutting-edge gut health products.

The Evolution of the biotikur Product Line

 

The Berlin-based startup strives to be approachable and empathetic.

“One tremendous asset that we have is that biotikur is personal, and it’s authentic,” the startup team shares. “The products and the ethos we’re putting out are really aligned with what we want to see in the world.”

This same ethos has driven the development of their first product: the 14-Day Regimen, which features a blend of probiotics and prebiotics, and includes a rectal application. 

What was novel about the product, and supported by evidence, was the direct application of probiotics in order to maximize the levels of good bacteria in the gut microbiome.

Since then, of course, biotikur has released additional products – including oral products – based on peer-reviewed science and real challenges people face. The team believes in integrating an educational element into each product, or something that directly helps consumers improve their nutrition and overall gut health.

The results are in, and consumers are interested. biotikur currently has a waiting list, though they are on the cusp of developing a ready-to-order subscription bundle called biotikur balance (a pre- and probiotic oral supplement made with more than 50 high-quality plant ingredients).

 

When biotikur joined Vision Health Pioneers, they were focused on their product above all else: on getting it developed, tested and in the hands of their users.

The incubator, however, helped them take that focus to the next level – allowing biotikur to ensure they were asking the right questions, undergoing the correct processes and truly optimizing their company for the right people.

“Just that support, and being able to learn from the journeys of other startups in the cohort, was super valuable for us,” says Mahmood. “I don’t think we could have achieved what we did on the scale we did, and as quickly as we did, without the support of Vision Health Pioneers.”

The truth is that all early-stage startups benefit from the unique energy of their peers. There’s a sense of genuine excitement as it relates to working on new and exciting – and, of course, necessary – topics.

“With startups, there are always more questions than answers,” Mahmood continues. “It’s really easy to feel overwhelmed, but VHP has that environment of energy and fresh motivation.”

While things are different in lockdown, young startups can and will persist through the pandemic. To that end, incubators aren’t going anywhere either. Being in a place with other passionate, likeminded people can be very energizing.

“It can be quite a grab bag, and also quite up and down when you’re dealt with setbacks,” Mahmood confesses.

But when there are successes, or even small successes, a group environment can make all the difference. There’s a genuine strength in numbers, and we all benefit from being around people who are going through similar experiences.

This, perhaps, brings us right back to the importance of gut health. The gut microbiome can be managed effectively with the right tools – because to varying degrees, it is something we all must deal with. And biotikur is here to transform the way we manage it.

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Inside the incubator

Inspired by Mothers: Developed for Women Everywhere

The idea for hers came from an unlikely but empowering place.

“I was working a few years ago with a gynaecologist on a research project where I designed pessaries, which are silicone devices that support the pelvic floor from inside of the vagina,” explained Yair Kira, cofounder and CEO of hers. “After this project ended, I realized there are new technologies that can be introduced to this space”.

Kira comes from a 3D printing world, and the potential of an individualized solution deeply inspired him. Yet hers came from a much more personal place than that. During this same research project, Kira’s mother approached him.

“She said, ‘Yair, maybe you can find a solution for my problem,’” Kira recalled.

From this seemingly innocuous conversation, the start-up’s CEO became aware of the true extent of the need for the product. “The more I started to work on it, the more I saw women just openly talking about their pelvic health challenges.”

And so hers was born. With cofounder Hugo Silva by his side and later Linda Wonneberger, now CMO, Kira cultivated a tangible, medically-based solution for pelvic floor dysfunctions (many of which may cause incontinence and other issues). The three entrepreneurs have developed a soft silicone inflatable device providing individualized support for the pelvic organs. Used in tandem with the hers app, which offers long-term pelvic floor training, women can take back control of their health – all while connecting with like-minded people and medical professionals.

“My mom always wanted to be the first customer,” Kira confessed. “I think for her, it’s great to know a solution that works for her will also be a solution for a million other women around the world.”

hers seeks to do just that – to help women from across the globe overcome their pelvic health challenges in the earliest possible stages of their pelvic organ descensus. The device presents a smart and easy solution that women can use at home. Made with biocompatible silicone that inflates inside the vagina, the hers pessary is a custom solution for women, designed with each person’s pelvic floor in mind.

A simple electric pump allows women to save their individualized settings. From there, the pessary adjusts to the right fit for the patient in question. Women can wear it daily similar to wearing a menstrual cup. The support of the device will provide them an immediate relief from the symptoms while strengthening their pelvic floor by interacting with the app and completing muscle training exercises throughout the day.

Kira explains the point of sale is all about offering an innovative solution: that of a connected device designed exclusively for women. The custom fit and long-term treatment approach is unprecedented in the women’s health space.

Entrepreneurs Empowering Women

 

“Half of the women population will experience pelvic floor dysfunctions during their lifetime,” the hers founders describe. “But there is a big taboo around it.”

And so, the entrepreneurs have launched a start-up with the goal to open the discussion and fill the gaps in knowledge surrounding this topic.

“In history, women have been under-represented when it comes to medical issues,” says Wonneberger, CMO of hers. “This is also a reason why women have learnt to be ashamed of the health issues they have.”

The hers team truly makes a point of encouraging women to engage in candid discussions about their health. By doing so, women can begin to care for their pelvic floor far earlier than menopause, and as a result, shed light on common issues by treating them in the very beginning stages.

It’s an empowering approach meant to put women’s health back in the hands of – you guessed it – women.

And hers’ three founders have witnessed first-hand the impact of their approach. While shadowing doctors at the Pelvic Floor Centre in Berlin, they interviewed a number of women patients and found just how important it is to provide a listening ear – to humanize medical care, if you will.

“Patients just want someone that will hear their story,” Kira said of their role. “Someone who won’t treat them as part of a machine, like a car that goes to the garage, gets something fixed and then goes away.”

In the same way the entrepreneurs believe healthcare should be personalized, the FemTech start-up has found that treatments should be personal. Women deserve the opportunity to tell their stories and be heard.

“So many women talk about it,” Wonneberger added. “They say, ‘You know, I’m 55, and I love my life. But when I go outside, I have to calculate exactly where the next toilet is. If it’s more than half an hour away, I cannot go to play with my grandchildren because I’m in fear of incontinence. So I’m staying at home.”

This, the entrepreneur explains, affects women’s lives more than most could possibly imagine. And how could anyone fathom what these patients go through, when taboo yet treatable pelvic health challenges are only rarely talked about?

The Power of Diversity in FemTech

 

The hers team is one of measurable diversity – not only in terms of gender and religion, but in background as well.

“I think having a diverse team is a big advantage, because Hugo Silva and I are maybe in some parts similar – we both come from product design, or industrial design – but we managed to do a separation,” says Kira.

As CTO, Silva is now spearheading the start-up’s design and development – including the corporate identity, user-focused design of the app and hardware, all according to the regulatory requirements. Kira is focused on the broader view and the financial side of things. Wonneberger, meanwhile, as CMO, offers a women’s point of view, plus extensive experience as a female founder in the FemTech space. The seasoned entrepreneur is behind companies such as Comfexy GmbH, CUCA BY LINDA and LindaBra.

“We have clear responsibilities in different areas,” states Wonneberger, “and we connect quite well because obviously, Yair [Kira] has lots of experience working with gynaecologists and in that area.”

The hers team boasts a growing network of gynaecologists Kira has cultivated from the early stages of his career and through their time in the Vision Health Pioneers incubator. They’ve gained strong connections over the years.

“And the fact that we had a gynaecologist as our key manager who could connect us with her peers,” Kira adds, “that was a really big advantage.”

Beyond the Incubator

 

Though leaving the incubator is daunting in theory, practically speaking, the hers team is ready for the next step in their entrepreneurial journey.

The early-stage hardware FemTech start-up is looking to secure 500,000 Euros to develop the hardware component of their device, along with their app, and connect with business angels who might be willing to join them in realising the vast potential of the pelvic health field.

“Our goal is to become one of the most successful FemTech companies by offering millions of women around the world an effective treatment for pelvic floor dysfunctions,” they describe in their three-year vision. “And together with them, to expand the knowledge and awareness around the pelvic floor.”

By continuing to increase awareness in this way, hers will introduce women to a powerful network, allowing them to treat common issues and ultimately feel heard. The start-up is deeply committed to making it happen.

 

Want to see team hers in action?

Watch their pitch from the Vision Health Pioneers Demo Day right here! See what they achieved during their time at the incubator and get a clear understanding of their product:

 

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Our Mentors

Startup Advice: Hiring for a Young Startup – 6 Strategies

As we move into 2021, companies are transitioning from a mindset of adaptation to strategic planning. In many cases, this includes exploring new growth opportunities and recruiting new team members. As the incubator time for batch #1 comes to an end, many of our portfolio startups – such as MySkills, Biotikur and advosense – are expanding their teams as well and are looking for great candidates. Since the team is one of the most important factors for success in early-stage companies, a few months ago we invited one of the most experienced female founders for a special session. Inga Bergen, a serial entrepreneur, digital health expert, and former CEO of the startup Magnosco, not only founded her own company from scratch but also took over management roles in established scale-ups where she expanded teams from 60 employees to a few hundred. In one special online session, she shed light on how to move forward during these unprecedented times and shared her learnings as a seasoned manager. Here are six hiring strategies she pointed out for early-stage founders:

1. Opt for a more experienced candidate.

Young startups benefit from having team members who are driven, committed to the company and well-equipped for the job. When it comes to making a hiring decision, experienced candidates are generally a safer bet. In the healthcare space, for instance, Inga Bergen recommends screening candidates to make sure they’re familiar with medical product development. The more experience a person has, the more knowledge and value they’ll bring to the table.

2. Know which roles to outsource and which ones to fill in-house.

The truth is that where investor readiness is concerned, it’s essential that startups keep all the key knowledge in-house. What does this mean? For example, if your solution is based on artificial intelligence, your startup should steer clear of outsourcing data scientists. Keeping the most important roles in-house – and the algorithm, in this case – can help to maintain productivity, all while maximizing security and efficiency. It’s a win-win.

3. Determine the right time to hire.

Inga Bergen operates with a simple rule in mind: She only hires new staff when she’s certain she can cover three to six months of that person’s salary or can offer attractive packages including shares in the company. The truth is that for any new startup, there’s quite a bit of demand – particularly in the beginning stages – to fill additional roles. This, however, isn’t always feasible. And so for young startups, founders must fix their finances first and only then figure out when to hire new staff.

4. Hone in on senior staff first.

The successful female founder has seen it all – and in several startups, she has witnessed founders building full teams when they should instead have hired their senior staff first. Say, for instance, the founders of a young startup decide they must hire a few new people. Rather than sourcing one senior product manager and three team members to work underneath them at the same time, you should recruit senior staff first to build his or her own team step by step. This will keep senior team members from imploding due to being given too much responsibility (and too little power) early on.

5. Opt for 15-minute phone screenings.

Though founders may want to meet with every prospect they find interesting, this isn’t an efficient use of their time – far from it, in fact! Inga Bergen recommends instead that young startups kick off the recruitment process with 15-minute phone screenings. To boost productivity, she suggests cold-calling them to get a feel for the interest and expertise level of potential candidates. From prospects’ motivation and energy to their drive and interest level, there’s a lot to glean from these brief conversations. 

6. Follow your gut.

This is a simple hiring practice, but it is perhaps the most important one of all: When making hiring decisions, founders should be patient and follow their instincts first. Bergen said that she always turns down prospective employees who she doesn’t have a good gut feeling about. She said she’d much rather prolong her search and wait for the right hire than make the wrong hiring decision; this protocol would ultimately leave the startup better off in the long run. This is necessary for healthcare startups in the early investment stages, she added.

PS: Make sure to get all the startup advice from our coaches and mentors by subscribing to our newsletter!

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Inside the incubator

Welcome Batch #2 of Vision Health Pioneers

The time has come to introduce our Batch #2 teams to you!

In January 2021 we welcomed 21 young founders with 13 different nationalities into our program. Out of 140+ applicants they convinced a jury of experts and conquered the multi-stage selection process of our incubator. 17 of them had a long journey to kick-off their healthcare startup in Berlin. They came from Italy, Spain, the Netherlands, the US, Austria and other countries to join our startup hub.

We are very excited as well to tackle new sectors this year. Besides solutions in FemTech and MentalHealth we will now also support your teams to address problems in Dermatology, Pulmonology and Cardiology.

We will explore how Art and Music can be applied. We will explore how smart textiles and hardware can provide new data. We will also explore how remote care can be improved. 

Please meet our Batch #2 Startups 

 


Alma is revolutionising how female intimate health is tackled in society.

Alma combines technology with education to enable females to become aware of their own bodies. The Italian teams first product is a smart underwear that monitors vaginal infections through pH sensing and supports the user with access to medical information, female community and healthcare professionals.

Team: Giulia Tomasello & Tauras Stalnionis


ArtMonia by karis is a digital therapeutic Virtual Reality game for the long-term treatment of Attention Deficit and Hyperactivity Disorder (ADHD). 

The Spanish team uses cutting-edge biomarkers to track the progression of this disorder with artistic stimuli that train emotional self-management and other cognitive aspects. 

Team: Rubén Nieto López, David Garrido Leal & Alissa Del Toro


Breaz is on a mission to detect breathing diseases early. 

The three entrepreneurs from the UK, Austria and India develop new medical devices with a user-centric approach to allow patients to receive an early diagnosis, empowering them to take control of their disease. Website

Team: James HugallPetra Stockinger & Ramvinojen Narayana Perumal


Skinuvita is developing digital solutions for a medically supervised home-treatment of chronic skin diseases with UV-Therapy.

Effective treatment requires 3-6 sessions per week within 2 months. Skinuvita addresses this by developing smart e-health solutions which enable a safe and medically supervised home-treatment. 

Team: Jan B. Elsner, Bojana PetkovichNadine Arrestegui Hermoza & Till Fitzke


Minime is a therapy diary-app for an evidence-based psychotherapeutic healing journey. 

Minime will replace paper self-observation protocols with an intuitive and educational user input. It helps patients with mental disorders to perceive and evaluate their own patterns and to try out and evaluate new ones. 

Team: Paul SchneeweißSepideh RazazzadehStella Römhildt & Nina Hackenbroich


Wavy Assistant is an AI assistant app that allows INOCA patients to manage their symptoms and lower their stress.

The Dutch startup combines qualitative data and quantitative data to build a personalised health profile. When the AI detects stress, the user can lower their stress by doing special music listening exercises. Website

Team: Lian Kuiper & Steve Thijssen


 

Excited to see their entrepreneurial journey?

Make sure you get all the Batch #2 updates and keep up with all future Vision Health Pioneers Incubator announcements by subscribing to our newsletter!